Therefore, research on prevention of aging, treatment of aging-related diseases, and improvement of vitality and quality of life is underway. GP alleviated liver and brain injuries by regulating oxidative stress and modulating the composition and metabolism of the gut microbiota.Īging is an inevitable and multifactorial process characterized by progressive decline in antioxidant function and subsequence increase in oxidative damage caused by reactive oxygen species and other oxidation products ( Forman, 2016 Galkin et al., 2019). Abundance of the gut microbiota differed significantly between GP and control groups. GP increased the activity of antioxidant enzymes, reduced malondialdehyde levels in the brain and serum, alleviated D-galactose–induced damage to the liver, and ameliorated mild cognitive impairment.

Gracilariopsis lemaneiformis polysaccharide (GP) exerted protective effects in an aging mouse model administered with D-galactose, and its mechanism was revealed.

3National Engineering Research Laboratory of marine biotechnology and Engineering, Key Laboratory of Marine Biotechnology of Zhejiang Province, School of Marine Sciences, Ningbo University, Ningbo, China.

2Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.

1Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou, China.

Zhongshan Zhang 1* Xinyue Li 1 Xiaogang Xu 2 Genxiang Mao 2 Xue Sun 3 Nianjun Xu 3* Xiaomei Wang 1*

Siberian girl mouse set mm 30